Shot answer. I think that scientists donât know for sure, and t skipped to say that, as well as do the research on it. What I mean by that is, t know there is a risk from that, however t chose to focus their efforts elsewhere. Because of that, there are no studies to base questions about DNA damage from mRNA vaccine! Itâs the oldest trick in the book. Scientists cannot say something is scientifically valid unless t have proven it with findings from studies t did on it. But, if there are no studies, then there are no findings to validate anything like that! So, scientists didnât do any studies, and as a result, t didnât make any findings. And, when asked such questions, t present the questions as claims. Then, t say that those claims are invalid, because there are no such scientific findings! In short, there is no scientific evidence, because t didnât try to find any! Scientists deceived people on this topic. T know there is a basis for which t could do research. But t didnât do that research. And t deceive people by omitting to state that there is a basis for such concerns, which does stand as a good reason to do research, and that t didnât do research on it. Shortly, that basis involves both the direct and indirect effects of mRNA vaccines to human DNA, the part of the DNA structure which t change, epigenetics, and the transgenerational effects adverse of mRNA vaccines. This is a very complex topic, complex in a way that I havenât found anyone else discussing it. According to scientific findings sofar, mRNA vaccines do not change someoneâs DNA. The reasoning t provide is that the mechanism by which mRNA vaccines act doesnât reach someoneâs DNA. I am asking a few interesting questions here. Is this answer fully valid? The key question regarding that. Which part of the human DNA is it referring to? The primary structure of the DNA, or any part of the DNA at all? I think that the above answer is referring only to the primary DNA structure. Do mRNA vaccines aim to change someoneâs DNA ie does their mechanism of action target the DNA? I think that the above answer implies that it mRNA vaccines donât target the DNA structure. But the question people are asking is, do mRNA vaccines change any DNA structures, even if t are not targeting it? Do mRNA vaccines change someoneâs DNA directly? I think that the above answer implies that mRNA vaccines do not change it directly. However, the question is whether it can change DNA indirectly, as a result of any other consequences t bring? Why do people who ask whether mRNA vaccines will change their DNA do so? Are t referring âwhether their DNA changes, or do t mean, âWill the vaccines cause any damage which is inheritable?â ie are the referring to damage to themselves, or damage to their offspring? I think t are referring to damages to their offspring. And, I think that t are asking about changes mRNA vaccines may cause to any DNA structure, not only the primary one, either mRNA vaccines aim for that or not, and either t would cause that directly or indirectly. And the question also asks whether mRNA vaccines cause epigenetic changes. Ultimately, I think the question is whether mRNA vaccines cause any inheritable or transgenerational effects at all, however t vaccines would do that! To answer questions such as the above. someone needs to know a little about that all these biology and medical terms mean, how relevant mechanisms work, and current findings regarding these. What is DNA? âDNA, or deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a personâs body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA). Mitochondria are structures within cells that convert the energy from food into a form that cells can use.â So, what people who ask about whether mRNA vaccines against COVID-19 change someoneâs DNA is, is whether t will cause some damage which will be passed on to their offspring ie their children and grand-children. Inherited disorders There are four types of genetic disorders (inherited). Single gene inheritance Multifactorial inheritance Chromosome abnormalities Mitochondrial inheritance 1. Single gene inheritance disorders Single gene inheritance is also called Mendelian or monogenetic inheritance. Changes or mutations that occur in the DNA sequence of a single gene cause this type of inheritance. There are thousands of known single-gene disorders. These disorders are known as monogenetic disorders (disorders of a single gene). Single-gene disorders have different patterns of genetic inheritance, including autosomal dominant inheritance, in which only one copy of a defective gene (from either parent) is necessary to cause the condition; autosomal recessive inheritance, in which two copies of a defective gene (one from each parent) are necessary to cause the condition; and X-linked inheritance, in which the defective gene is present on the female, or X-chromosome. X-linked inheritance may be dominant or recessive. Some examples of single-gene disorders include cystic fibrosis, alpha- and beta-thalassemias, sickle cell anemia (sickle cell disease), Marfan syndrome, fragile X syndrome, Huntington's disease, and hemochromatosis. 2. Multifactorial genetic inheritance disorders Multifactorial inheritance is also called complex or polygenic inheritance. Multifactorial inheritance disorders are caused by a combination of environmental factors and mutations in multiple genes. For example, different genes that influence breast cancer susceptibility have been found on chromosomes 6, 11, 13, 14, 15, 17, and 22. Some common chronic diseases are multifactorial disorders. Examples of multifactorial inheritance include heart disease, high blood pressure, Alzheimer's disease, arthritis, diabetes, cancer, and obesity. Multifactorial inheritance also is associated with heritable traits such as fingerprint patterns, height, eye color, and skin color. 3. Chromosomal abnormalities Chromosomes, distinct structures made up of DNA and protein, are located in the nucleus of each cell. Because chromosomes are the carriers of the genetic material, abnormalities in chromosome number or structure can result in disease. Chromosomal abnormalities typically occur due to a problem with cell division. For example, Down syndrome (sometimes referred to as "Down's syndrome") or trisomy 21 is a common genetic disorder that occurs when a person has three copies of chromosome 21. There are many other chromosomal abnormalities including. Turner syndrome (45,X0), Klinefelter syndrome (47, XXY), and Cri du chat syndrome, or the "cry of the cat" syndrome (46, XX or XY, 5p-). Diseases may also occur because of chromosomal translocation in which portions of two chromosomes are exchanged. 4. Mitochondrial genetic inheritance disorders This type of genetic disorder is caused by mutations in the non-nuclear DNA of mitochondria. Mitochondria are small round or rod-like organelles that are involved in cellular respiration and found in the cytoplasm of plant and animal cells. Each mitochondrion may contain 5 to 10 circular pieces of DNA. Since egg cells, but not sperm cells, keep their mitochondria during fertilization, mitochondrial DNA is always inherited from the female parent. Examples of mitochondrial disease include Leber's hereditary optic atrophy (LHON), an eye disease; myoclonic epilepsy with ragged red fibers (MERRF); and mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), a rare form of dementia. Ways in which DNA can be damaged DNA can be damaged via environmental factors as well. Environmental agents such as UV light, ionizing radiation, and genotoxic chemicals. Replication forks can be stalled due to damaged DNA and double strand breaks are also a form of DNA damage. Epigenetics, and transgenerational effects of vaccines Epigenetics is the study of how your behaviors and environment can cause changes that affect the way your genes work. Unlike genetic changes, epigenetic changes are reversible and do not change your DNA sequence, but t can change how your body reads a DNA sequence. Transgenerational epigenetic inheritance is the transmission of epigenetic markers from one organism to the next (i.e, from parent to child) that affects the traits of offspring without altering the primary structure of DNA (i.e. the sequence of nucleotides)âin other words, epigenetically. Transgenerational effects (TGE) can modify phenotypes of offspring generations playing thus a potentially important role in ecology and evolution of many plant species. These effects have been studied mostly across generations of sexually reproducing species. As the paper âCOVID-19 vaccine safetyâ writes . âAn overlooked issue associated with the vaccine discussions is potential transgenerational effects. Transgenerational studies of adverse substance effects tend to be focused on environmental causes; however, there are some examples of such studies for drugs. A previous study on chemotherapy-induced late transgenerational effects (38) has raised some concerns, both due to the scarcity of such studies in the literature and the transmission of adverse effects deep in the generational chain. Due to the inadequate safety testing of several toxic stimuli in the past (including vaccines), it remains uncertain as to whether a number of diseases currently affecting humanity may be due in part to the actions of our predecessors passed on to us through transgenerational effects. It is uncertain as to whether any of the drugs, vaccines, foods or radiation exposures of our predecessors, which were not tested for transgenerational effects, are adversely affecting human life at present. Of note, the question remains whether humanity is currently willing to pass on potential devastating diseases to future generations due to the present need for the speedy development of a vaccine, bypassing adequate long-term and transgenerational safety testing.â Epigenetic modification categories As Wikipedia writes, four general categories of epigenetic modification are known . self-sustaining metabolic loops, in which a mRNA or protein product of a gene stimulates transcription of the gene; e.g. Wor1 gene in Candida albicans; structural templating in which structures are replicated using a template or scaffold structure on the parent; e.g. the orientation and architecture of cytoskeletal structures, cilia and flagella, prions, proteins that replicate by changing the structure of normal proteins to match their own; chromatin marks, in which methyl or acetyl groups bind to DNA nucleotides or histones thereby altering gene expression patterns; e.g. Lcyc gene in Linaria vulgaris described below; RNA silencing, in which small RNA strands interfere (RNAi) with the transcription of DNA or translation of mRNA; known only from a few studies, mostly in Caenorhabditis elegans. So, to answer the original question, I am asking these questions. Can mRNA vaccines damage any other than the primary structure of the DNA? Do mRNA vaccines against COVID-19 cause epigenetic modifications? Can t cause epigenetic modifications indirectly, as a consequence of their primary effects? Do mRNA vaccines cause any transgenerational epigenetic effects? Do mRNA vaccines cause any transgenerational effects at all, even if the primary DNA structure is not damaged?
No. In fact, you have to remember that retroviruses have a limited lifespan. As soon as they get into a living cell they die or their DNA is destroyed or degraded.